STK11 LOSS Detail (hg19) (STK11)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr19:1,205,740-1,228,428 |
| hg38 | chr19:1,205,741-1,228,429 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| lung non-small cell carcinoma | Docetaxel,Selumetinib | D |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 22425996 | Detail |
| Peutz-Jeghers syndrome | Sirolimus | D |
Predictive
|
Supports
|
Sensitivity/Response | Rare Germline | 1 | 18281551 | Detail |
| Peutz-Jeghers syndrome | Sirolimus | D |
Predictive
|
Supports
|
Sensitivity/Response | Rare Germline | 1 | 19541609 | Detail |
| lung non-small cell carcinoma | Sirolimus,Everolimus | D |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 26027660 | Detail |
| Peutz-Jeghers syndrome | B |
Predisposing
|
Supports
|
Positive | Rare Germline | 3 | 12865922 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| A clinical trial comparing selumetinib and docetaxel vs. docetaxel and placebo in KRAS mutant NSCLC ... | CIViC Evidence | Detail |
| Preclinical study in a mouse model of Peutz-Jeghers syndrome. Heterozygous Lkb1 (STK11) knockout mic... | CIViC Evidence | Detail |
| Treatment of mice with a heterozygous loss of Lkb1 (STK11) with rapamycin led to reduction in polyp ... | CIViC Evidence | Detail |
| Preclinical study in 5 NSCLC cell lines. Two LKB1 (STK11) mutant cell lines had higher basal levels ... | CIViC Evidence | Detail |
| In a series of 33 patients with Peutz-Jeghers Syndrome, 17 mutations in STK11/LKB1 were observed in ... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- STK11
- Genome
- hg19
- Position
- chr19:1,205,740-1,228,428
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- LOSS
- Transcript 1 (CIViC Variant)
- ENST00000326873.7
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/485
Genome browser